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Catalog Number | orb1679749 |
---|---|
Category | Small Molecules |
Description | Orexin A (human, rat, mouse) |
MW | 3561.1 |
CAS Number | 205640-90-0 |
Formula | C152H243N47O44S4 |
SMILES | C([C@@H](NC(=O)[C@H]1N(C(=O)[C@@H]2CCC(=O)N2)CCC1)CC(C)C)(=O)N3[C@H](C(N[C@H](C(N[C@@H]4C(=O)N[C@@]5(C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@]([C@@H](C)O)(C(=O)N[C@@](CSSC4)(C(=O)N[C@@H](CO)C(=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC6=CC=C(O)C=C6)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC7=CN=CN7)C(NCC(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC8=CN=CN8)C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N)=O)=O)[C@@H](C)O)=O)CC(C)C)=O)[C@H](CC)C)=O)=O)C)=O)C)=O)=O)CC(N)=O)=O)=O)C)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)CCC(O)=O)=O)=O)CC(C)C)=O)CCCNC(=N)N)=O)CSSC5)[H])[H])[H])=O)CC(O)=O)=O)CCC3 |
Storage | -20°C |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
> 95% | |
3565.14 | |
Synthetic |
> 95% by hplc | |
3561.12 Da | |
Glp-Pro-Leu-Pro-Asp-*Cys-*Cys-Arg-Gln-Lys-Thr-*Cys-Ser-*Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (*disulphide bridges between cysteines 6 and 12, and cysteines 7 and 14) |
For example, if the dosage of your experiment is 10mg/kg, the weight of each animal is 50g, and the volume of the dosing is 100μL, then the working solution concentration of your experiment is 5mg/mL. If the formula you used is 5% DMSO+ 30% PEG300+ 5% Tween 80 + 60% Saline/PBS/ddH2O, the preparation method is as follows:
Mother liquor preparation method: 5mg of drug dissolved in 100μL DMSO (mother liquor concentration is 50mg/mL). Preparation method of in vivo formulation: For 1mL of working solution preparation, take 50μL of DMSO mother liquor, add 300 μL of PEG300 to mix well and clarify, then add 50μL of Tween-80 to mix well and clarify, and finally add 600μL of Saline/PBS/ddH2O to mix well and clarify.