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Catalog Number | orb216741 |
---|---|
Category | Proteins |
Description | Orexin A Human, Mouse Rat, Bovine, Canine, Ovine, Porcine peptide |
CAS Number | 205640-90-0 |
Form/Appearance | Lyophilized powder |
Purity | > 95% |
MW | 3565.14 |
Formula | C152H247N47O44S4 |
Protein Sequence | pGlu-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (Disulfide bridge Cys6-Cys12, Cys7-Cys14) |
Source | Synthetic |
Storage | Shipped at 4°C. Store at -20°C for one year. |
Alternative names | Hypocretin-1 (human, bovine, canine, mouse, ovine, Read more... |
Note | For research use only |
Application notes | Orexin A (hypocretin-1) is a hypothalamic neuropeptide regulating the feeding behavior. Central administration of orexin A to rats stimulated food consumption in a dose-dependent manner. The effect persisted at 4 h after injection, as orexin A seems to be resistant to peptidases. Orexin A specifically binds a G protein-coupled receptor, OX₁R (IC₅₀ = 20 nM to displace 50 % of radiolabeled orexin A bound to this receptor). Orexin A produced in the amygdala induces wakefulness and plays a role in the induction of human emotions. Narcolepsy has been associated with orexin deficiency. |
Expiration Date | 12 months from date of receipt. |
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