Orexin A Human, Mouse Rat, Bovine, Canine, Ovine, Porcine peptide

• Catalog Number: orb216741
• Category: Proteins
• Description: Orexin A Human, Mouse Rat, Bovine, Canine, Ovine, Porcine peptide
• Form/Appearance: Lyophilized powder
• Purity: > 95%
• Protein Sequence: pGlu-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (Disulfide bridge Cys6-Cys12, Cys7-Cys14)
• MW: 3565.14
• Application notes: Orexin A (hypocretin-1) is a hypothalamic neuropeptide regulating the feeding behavior. Central administration of orexin A to rats stimulated food consumption in a dose-dependent manner. The effect persisted at 4 h after injection, as orexin A seems to be resistant to peptidases. Orexin A specifically binds a G protein-coupled receptor, OX₁R (IC₅₀ = 20 nM to displace 50 % of radiolabeled orexin A bound to this receptor). Orexin A produced in the amygdala induces wakefulness and plays a role in the induction of human emotions. Narcolepsy has been associated with orexin deficiency.
• Source: Synthetic
• CAS Number: 205640-90-0
• Formula: C₁₅₂H₂₄₇N₄₇O₄₄S₄
• Storage: Shipped at 4°C. Store at -20°C for one year.
• Alternative names: Hypocretin-1 (human, bovine, canine, mouse, ovine,
• Note: For research use only