Omadacycline

SKU: orb1221165

Description

Omadacycline a new tetracycline antibiotic can inhibit the 30s subunit of bacterial ribosome.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 389139-89-3
• MW: 556.65
• Purity: >98% (HPLC)
• Formula: C₂₉H₄₀N₄O₇
• SMILES: CN(C)[C@H]1[C@@H]2C[C@@H]3Cc4c(cc(CNCC(C)(C)C)c(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)N(C)C
• Target: Antibacterial
• Solubility: DMSO: 10 mM

Bioactivity

• In Vivo:
  Omadacycline (0.11-18 mg/kg; a single i. v.) exhibits efficacy against Streptococcus pneumonia, Escherichia coli, and Staphylococcus aureus in mice systemic infection model, with ED50s ranging from 0.30 mg/kg to 3.39 mg/kg.
  Read more...
• In Vitro:
  Omadacycline displays activity against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), beta-hemolytic streptococci, penicillin-resistant Streptococcus pneumonia (PRSP) and Haemophilus influenzae (H. influenzae), with MIC90s of 1.0, 0.25, 0.5, 0.25 and 2.0 μg/mL respectively. Omadacycline is active against strains expressing tetracycline and other antibiotics resistance by ribosomal protection and active tetracycline efflux.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Amadacycline | PTK 0796

Quick Database Links

Gene Symbol

Antibacterial