Olprinone

SKU: orb1221326

Description

Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB).(In Vivo):Olprinone (Loprinone) Hydrochloride (0.2 mg/kg; i.p.) modulates the inflammation associated with myocardial ischemia-reperfusion injury in rats.

Key Properties

• CAS Number: 106730-54-5
• MW: 250.26
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₀N₄O
• SMILES: Cc1[nH]c(=O)c(cc1-c1ccc2nccn2c1)C#N
• Target: PDE
• Solubility: DMSO:10mM

Bioactivity

• In Vivo:
  Olprinone (Loprinone) (0.2 mg/kg; i.p.) modulates the inflammation associated with myocardial ischemia-reperfusion injury in rats. Animal model: Male adult Wistar rats (250-300 g) (ischemia–reperfusion rats). Dosage: 0.2 mg/kg. Administration: i.p. (administered 15 min after ischemia). Result: Significantly reduced the: (1) histological evidence of myocardial injury, (2) pro-inflammatory cytokines: tumor necrosis factor-α (TNF-α) and Interleukin-1β (IL-1β), (3) adhesion molecules: Inter-Cellular Adhesion Molecule 1 (ICAM-1) and P-Selectin, (4) nitrotyrosine formation, (5) nuclear factor kappa-B (NF-κB) expression, (6) Poly (ADP-ribose) (PAR) formation, and (7) apoptosis (Bax, Bcl-2, Fas-L and terminal deoxynucleotidyl transferase-mediated UTP end labeling (TUNEL).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Loprinone

Quick Database Links

Gene Symbol

PDE