Octopamine hydrochloride

SKU: orb1310582

Description

Octopamine hydrochloride is the racemic form of a noradrenaline analog that functions as a key neuroactive molecule in invertebrates. It is widely used in research to study neurotransmitter systems, receptor pharmacology, and insect neurobiology in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 770-05-8
• MW: 189.64
• Purity: ≥98% (May vary between batches)
• Formula: C₈H₁₂ClNO₂
• SMILES: Cl.NCC(O)c1ccc(O)cc1
• Target: Endogenous Metabolite,Dopamine Receptor,Adrenergic Receptor
• Solubility: DMSO:16.67 mg/mL (87.9 mM);H2O:200.4 mM

Bioactivity

• In Vivo:
  Octopamine (10 mg/mL) is necessary for the acquisition of sugar memory in Drosophila. Octopamine treatment increases responsiveness to brood pheromone and decreased responsiveness to social inhibition. Octopamine acts as an important source of variation in response thresholds and as a modulator of pheromonal communication in insect societies. Octopamine (10 μM) injected into the mushroom body (MB) calyces or the antennal lobe but not the lateral protocerebral lobe produces a lasting, pairing-specific enhancement of extension of the proboscis. Octopamine (10 μM) injected into the MB calyces results in an additional pairing-specific effect, because it does not lead to an acquisition but a consolidation after conditioning. Octopamine treatment significantly elevates levels of octopamine in the brain and caused a significant dose-dependent increase in the number of new foragers. Octopamine treatment is effective only when given to bees old enough to forage, i.e., older than 4 days of age. Octopamine influences division of labor in honey bee colonies.
• In Vitro:
  Octopamine is present in relatively high concentrations in neuronal as well as in non-neuronal tissues of most invertebrate species studied, and modulates almost every physiological process. Octopamine acts as neurohormone including desensitization of sensory inputs, influence on learning and memory, or regulation of the mood of the animal in the central nervous system. Octopamine is the only neuroactive non-peptide transmitter whose physiological role is restricted to invertebrates, and all octopamine receptors belong to the family of G-protein coupled receptors.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

p-Octopamine hydrochlorid, memory, learning, EndogenousMetabolite, Endogenous Metabolite, Inhibitor, inhibit, invertebrates, Octopamine, Octopamine HCl, Octopamine hydrochloride, Octopamine Hydrochloride, neurotransmitter, neurohormone, neuromodulator, Adrenergic Receptor, AdrenergicReceptor, (+,-)-Octopamine HCl, (±)-p-Octopamine hydrochlorid, Beta Receptor, Dopamine, Dopamine Receptor, DopamineReceptor

Compound Identifiers

PubChem CID

102484