O4I2

SKU: orb1305489

Description

O4I2 is a potent small molecule activator of the pluripotency transcription factor Oct3/4. It effectively induces Oct3/4 expression in diverse human cell lines, such as fibroblasts, facilitating cellular reprogramming and stem cell research in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 165682-93-9
• MW: 282.75
• Purity: 99.84% (May vary between batches)
• Formula: C₁₂H₁₁ClN₂O₂S
• SMILES: CCOC(=O)C1=CSC(NC2=CC=C(Cl)C=C2)=N1
• Target: OCT
• Solubility: DMSO:28.3 mg/mL (100.09 mM);Ethanol:14.1 mg/mL (49.87 mM)

Bioactivity

• In Vitro:
  O4I2 activates Oct3/4 expression in HEK293 and embryonal NCCIT cells, and also in Oct-deficient HeLa and terminally differentiated human fibroblasts, and also induces other pluripotency-associated genes such as Lin28 and Nanog.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

4-10, 3-10, activator, cell, Inhibitor, inhibit, lin28, iPSCs, nanog, Oct3/4, O4I2, O-4I2, pluripotent, POU5F1, Rex1, stem, sox2, Slc22a3

Compound Identifiers

PubChem CID

53428670