NS1643

SKU: orb1304441

Description

NS1643 is a small molecule activator of the hERG (KV11.1) potassium channel, exhibiting an EC50 of 10.5 µM. It is a valuable research tool for studying cardiac electrophysiology, Long QT Syndrome, and arrhythmia mechanisms in both cellular and tissue-based experimental models.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 448895-37-2
• MW: 380.24
• Purity: 98.37% (May vary between batches)
• Formula: C₁₅H₁₀F₆N₂O₃
• SMILES: Oc1ccc(cc1NC(=O)Nc1cc(ccc1O)C(F)(F)F)C(F)(F)F
• Target: Autophagy,Potassium Channel
• Solubility: Ethanol:100 mM;DMSO:50 mg/mL (131.5 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.26 mM)

Bioactivity

• Target IC50:
  ERG (human):10.5 μM(EC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PotassiumChannel, Potassium Channel, inhibit, KcsA, NS1643, NS-1643, NS 1643, hERG, Inhibitor, Autophagy

Compound Identifiers

PubChem CID

10177784