Nonapeptide-1

SKU: orb1299524

Description

Nonapeptide-1 (Melanostatine™ 5) is a synthetic peptide that suppresses melanin production. It is utilized in dermatological research to study pigmentary disorders and has been investigated in both in vitro cell assays and in vivo models for potential skin-whitening applications.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 158563-45-2
• MW: 1206.5
• Purity: >99.99% (May vary between batches)
• Formula: C₆₁H₈₇N₁₅O₉S
• SMILES: CSCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O
• Target: Melanocortin Receptor,Others
• Solubility: DMSO:255 mg/mL (211.36 mM)

Bioactivity

• Target IC50:
  MC5R:2.4 μM (Ki)|MC4R:1.34 μM (Ki)|MC1R:40 nM (Ki)|MC3R:0.47 μM (Ki)

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

UVA, Skin pigmentation, HaCaT, melanin, Melanostatine 5, Melanostatine5, Melanostatine-5, Melanostatine 5, melanogenesis, melanocytes, Melanocortin Receptor, MC Receptor, HEM, Inhibitor, Nonapeptide1, Nonapeptide-1, Nonapeptide 1, inhibit, Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-

Compound Identifiers

PubChem CID

10418849