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Catalog Number | orb1981735 |
---|---|
Category | Small Molecules |
Description | Nonapeptide-1 (Melanostatine-5) acetate salt is a peptide hormone that functions as a selective and competitive antagonist of the melanocortin 1 receptor (MC1R) with a binding affinity (K i) of 40 nM. It effectively inhibits α-MSH-induced increases in intracellular cyclic AMP (cAMP) and melanosome dispersion in melanocytes, with inhibitory concentrations (IC 50) of 2.5 nM and 11 nM, respectively. By inhibiting melanin synthesis, Nonapeptide-1 acetate salt is used in research related to skin pigmentation, adrenal gland steroid production regulation, and skin cancer [1] [2] [3]. |
Purity | 98.00% |
MW | 1266.56 |
Formula | C63H91N15O11S |
Biological Activity | Nonapeptide-1 (Melanostatine-5) acetate salt, a peptide hormone, functions as a selective and competitive antagonist of the melanocortin 1 receptor (MC1R) with a binding affinity (K i) of 40 nM. It effectively inhibits α-MSH-induced increases in intracellular cyclic AMP (cAMP) and melanosome dispersion in melanocytes, showcasing inhibitory concentrations (IC 50) of 2.5 nM and 11 nM, respectively. By inhibiting melanin synthesis, Nonapeptide-1 acetate salt finds application in research related to skin pigmentation, adrenal gland steroid production regulation, and skin cancer [1] [2] [3]. |
Storage | -20°C |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
98.26% | |
1266.58 | |
C63H91N15O11S |