Nolatrexed dihydrochloride

SKU: orb1701525

Description

Nolatrexed dihydrochloride (Thymitaq) is a water-soluble, lipophilic quinazoline folate analog that acts as a potent thymidylate synthase inhibitor, disrupting thymine synthesis and leading to DNA damage, cell cycle arrest, and apoptosis. It has been investigated in vitro and in vivo for anticancer and radiosensitizing effects in various solid tumor models.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 152946-68-4
• MW: 357.26
• Purity: 97.02%
• Formula: C₁₄H₁₄Cl₂N₄OS
• SMILES: Cl.Cl.Cc1ccc2[nH]c(N)nc(=O)c2c1Sc1ccncc1
• Target: DNA/RNA Synthesis
• Solubility: DMSO:>10 mM;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.6 mM)

Bioactivity

• Target IC50:
  Folate cofactor:11 nM (Ki)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNASynthesis, DNA Synthesis, AG337, AG-337, AG 337, Inhibitor, inhibit, Nolatrexed, Nolatrexed dihydrochloride, Nolatrexed Dihydrochloride, Thymitaq, Thymidylate Synthase, Thymidylate synthase, RNA Synthesis, RNASynthesis

Compound Identifiers

PubChem CID

135409535