Nolatrexed dihydrochloride

SKU: orb1223273

Description

Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.

Images & Validation

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Key Properties

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CAS Number	152946-68-4
MW	357.26
Purity	>98% (HPLC)
Formula	C₁₄H₁₄Cl₂N₄OS
SMILES	Cc1c(c2c(cc1)[nH]c(N)nc2=O)Sc1ccncc1.Cl.Cl
Target	Thymidylate synthase
Solubility	DMSO : 41.67 mg/mL. 116.64 mM;

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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AG 337 | Thymitaq

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Gene Symbol

Thymidylate synthase

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