NKH 477 hydrochloride

SKU: orb2655932

Description

NKH 477 hydrochloride (Colforsin dapropate) is a water-soluble analog of Forskolin and a potent activator of adenylyl cyclase, shows some selectivity for cardiac (type V) adenylyl cyclase; increases cAMP accumulation in HEK293 cells stably overexpressing type V more than forskolin; A PKA activator.Heart Failure Approveed.

Key Properties

• CAS Number: 138605-00-2
• MW: 546.1
• Purity: >98% (HPLC)
• Formula: C₂₇H₄₃NO₈.HCl
• SMILES: CC(C)CCC(O[C@@H]([C@@]1([H])C(C)(C)CC[C@H](O)[C@@]12C)[C@H](OC(C)=O)[C@]3(C)[C@]2(O)C(C[C@](C)(C=C)O3)=O)=O.[H]Cl
• Target: Adenylate Cyclase
• Solubility: In Vitro: DMSO : 125 mg/mL (228.90 mM)

Bioactivity

• In Vivo:
  NKH477 (Colforsin dapropate hydrochloride) (orally; 1-3 mg/kg/day; days 3 and 5) prolonged lung allograft survival in a dose dependent manner. Animal model: Specific-pathogen-free inbred male Lewis rats (LEW) weighing 250 to 280 g. Dosage: 1, 2 or 3 mg/kg/day. Administration: Orally; daily; Days 3 and 5. Result: Prolonged lung allograft survival in a dose dependent manner.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Colforsin dapropate

Quick Database Links

Gene Symbol

Adenylate Cyclase