NKH477

SKU: orb1706906

Description

NKH477

Research Area

Neuroscience

Key Properties

• CAS Number: 138605-00-2
• MW: 546.09
• Purity: 98.00% (May vary between batches)
• Formula: C₂₇H₄₄ClNO₈
• SMILES: O[C@@]12[C@]3(C)[C@@]([C@H](OC(CCN(C)C)=O)[C@H](OC(C)=O)[C@@]1(C)O[C@](C=C)(C)CC2=O)(C(C)(C)CC[C@@H]3O)[H].Cl
• Target: AChR
• Solubility: H2O:10 mg/mL (18.31 mM);DMSO:80 mg/mL (146.5 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.16 mM)

Bioactivity

• In Vivo:
  In experimental dogs, intravenous administration of NKH477 (1-30 μg/kg) resulted in an increase in left ventricular dP/dtmax, coronary and femoral blood flow, heart rate, and myocardial oxygen consumption, as well as a decrease in blood pressure in anesthetized dogs. NKH477 is a useful insulin dilator for the treatment of heart failure.
• In Vitro:
  NKH477 (0.1-1.0 μM) inhibits ACh induced contraction in a concentration-dependent manner by attenuating ACh induced Ca2 + mobilization and reducing the sensitivity of the contractile mechanism to Ca2 +.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NKH 477, NKH477, NKH-477, Adenylate Cyclase, Colforsin dapropate hydrochloride

Compound Identifiers

PubChem CID

444028