Nimodipine

SKU: orb1310704

Description

Nimodipine

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 66085-59-4
• MW: 418.44
• Purity: 99.71%
• Formula: C₂₁H₂₆N₂O₇
• SMILES: C(OCCOC)(=O)C=1C(C(C(OC(C)C)=O)=C(C)NC1C)C2=CC(N(=O)=O)=CC=C2
• Target: Autophagy,Glucocorticoid Receptor,AhR,Calcium Channel
• Solubility: DMSO:130 mg/mL (310.68 mM);Ethanol:4.2 mg/mL (10.04 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.56 mM)

Bioactivity

• In Vivo:
  Nimodipine (5-20 mg/kg, SC) suppresses in a dose-related manner self-administration both of cocaine and morphine contingent upon a nose-poke response. Nimodipine (10 mg/kg, SC), an L-type dihydropyridine Ca2+ channel antagonist, exhibits to completely block the establishment of conditioning of cocaine's effects, but only partially blocks sensitization to cocaine.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AhR, CalciumChannel, Ca2+ channels, Calcium Channel, calcium, Ca channels, BAY-e 9736, Autophagy, dihydropyridine, cerebrovascular, inhibit, light-sensitive, Mineralocorticoid Receptor, Nimodipine, orally, GlucocorticoidReceptor, Glucocorticoid Receptor, Inhibitor, well-tolerated

Compound Identifiers

PubChem CID

4497