Nimodipine

SKU: orb1310704

Description

Nimodipine (BAY-e 9736) is a dihydropyridine-class calcium channel antagonist with selective activity on vascular smooth muscle. It is widely used in research to study cerebrovascular function and neuroprotection in models of subarachnoid hemorrhage, both in vitro and in vivo.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 66085-59-4
• MW: 418.44
• Purity: 99.79% (May vary between batches)
• Formula: C₂₁H₂₆N₂O₇
• SMILES: C(OCCOC)(=O)C=1C(C(C(OC(C)C)=O)=C(C)NC1C)C2=CC(N(=O)=O)=CC=C2
• Target: Autophagy,Glucocorticoid Receptor,AhR,Calcium Channel
• Solubility: DMSO:130 mg/mL (310.68 mM);Ethanol:4.2 mg/mL (10.04 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.56 mM)

Bioactivity

• In Vivo:
  Nimodipine (5-20 mg/kg, SC) suppresses in a dose-related manner self-administration both of cocaine and morphine contingent upon a nose-poke response. Nimodipine (10 mg/kg, SC), an L-type dihydropyridine Ca2+ channel antagonist, exhibits to completely block the establishment of conditioning of cocaine's effects, but only partially blocks sensitization to cocaine.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AhR, CalciumChannel, Ca2+ channels, Calcium Channel, calcium, Ca channels, BAY-e 9736, Autophagy, dihydropyridine, cerebrovascular, inhibit, light-sensitive, Mineralocorticoid Receptor, Nimodipine, orally, GlucocorticoidReceptor, Glucocorticoid Receptor, Inhibitor, well-tolerated

Compound Identifiers

PubChem CID

4497