Nimodipine

SKU: orb1224312

Description

Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy.(In Vitro):Nimodipine (1.5~150 μg/ml; 15 minutes; B16a and W256 cells) results in a dose-dependent inhibition of B16a and W256 tumor-cell-induced platelet aggregation. Nimodipine is also inhibitory in a homologous system.(In Vivo):Nimodipine (0.2 μg/μl, intrathecal administration) prevents subarachnoid hemorrhage-associated cerebral vasospasm by prophylactic continuous intrathecal administration.Nimodipine(0.1~80 mg/kg; p.o.) results in a significant dose-dependent inhibition of spontaneous metastasis.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 66085-59-4
• MW: 418.44
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₆N₂O₇
• SMILES: CC1=C(C(OCCOC)=O)C(C2=CC([N+]([O-])=O)=CC=C2)C(C(OC(C)C)=O)=C(C)N1
• Target: AhR
• Solubility: Ethanol: 84 mg/mL (200.74 mM); DMSO: 84 mg/mL (200.74 mM)

Bioactivity

• In Vivo:
  Nimodipine (0.2 μg/μl, intrathecal administration) prevents subarachnoid hemorrhage-associated cerebral vasospasm by prophylactic continuous intrathecal administration. Nimodipine(0.1~80 mg/kg; p.o.) results in a significant dose-dependent inhibition of spontaneous metastasis. Animal model: New Zealand white rabbits. Dosage: 0.2 μg/μl. Administration: Intrathecal administration. Result: Prevented subarachnoid hemorrhage-associated cerebral vasospasm by prophylactic continuous intrathecal administration.
• In Vitro:
  Nimodipine (1.5~150 μg/ml; 15 minutes; B16a and W256 cells) results in a dose-dependent inhibition of B16a and W256 tumor-cell-induced platelet aggregation. Nimodipine is also inhibitory in a homologous system.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Admon | BAY-e 9736 | Periplum

Quick Database Links

Gene Symbol

AhR