NIH-12848

SKU: orb1304067

Description

NIH-12848

Research Area

Signal Transduction

Key Properties

• CAS Number: 959551-10-1
• MW: 385.41
• Purity: 99.90%
• Formula: C₂₀H₁₄F₃N₃S
• SMILES: FC(F)(F)c1ccccc1-c1nc(NCc2cccs2)c2ccccc2n1
• Target: PI3K
• Solubility: DMSO:55 mg/mL (142.71 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.19 mM)

Bioactivity

• Target IC50:
  PI5P4Kγ:1 μM
• In Vitro:
  NIH-12848 inhibits the translocation of Na+/ K+-ATPase to the plasma membrane that occurs when mpkCCD cells grow to confluence and also prevents reversibly their forming of ‘domes' on the culture dish. NIH-12848 inhibits PI5P4Kγ with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. Both these NIH-12848-induced effects are mimicked by specific RNAi knockdown of PI5P4Kγ, but not that of PI5P4Ks α or β. NIH-12848 could be a potentially powerful tool for exploring the cell physiology of PI5P4Ks.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, NIH 12848, NIH12848, NIH-12848, PI5P4Kγ

Compound Identifiers

PubChem CID

3235425