NIH-12848

SKU: orb1222965

Description

NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor. NIH-12848 inhibited PI5P4Kγ with an IC50 of approximately 1 μM but did not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. NIH-12848 is a potentially powerful tool for exploring the cell physiology of PI5P4Ks.

Key Properties

• CAS Number: 959551-10-1
• MW: 385.41
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₄F₃N₃S
• SMILES: FC(F)(F)c1ccccc1c1nc2ccccc2c(NCc2cccs2)n1
• Target: Neurokinin Receptor
• Solubility: DMSO : ≥ 28 mg/mL; 72.65 mM

Bioactivity

• In Vitro:
  NIH-12848 inhibits PI5P4Kγ with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. NIH-12848 inhibits the translocation of Na+/ K+-ATPase to the plasma membrane that occurs when mpkCCD cells grow to confluence and also prevents reversibly their forming of ‘domes’ on the culture dish. Both these NIH-12848-induced effects are mimicked by specific RNAi knockdown of PI5P4Kγ, but not that of PI5P4Ks α or β. NIH-12848 could be a potentially powerful tool for exploring the cell physiology of PI5P4Ks.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NIH-12848 | NCGC00012848-02.

Quick Database Links

Gene Symbol

Neurokinin Receptor