NiCur

SKU: orb1689145

Description

NiCur

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 2674753-39-8
• MW: 324.38
• Purity: 99.22% (May vary between batches)
• Formula: C₂₂H₁₆N₂O
• SMILES: C(=C\1/C(=O)\C(=C\C2=CC(C#N)=CC=C2)\CCC1)\C3=CC(C#N)=CC=C3
• Target: Histone Acetyltransferase,PARP,Apoptosis,Epigenetic Reader Domain,Caspase
• Solubility: DMSO:40 mg/mL (123.31 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.08 mM)

Bioactivity

• Target IC50:
  CBP-HAT:0.35 μM
• In Vitro:
  When NiCur acts on U2OS cells within the concentration range of 0.5 - 1 μM, it can reduce Dox-induced p53K382ac, p53S15p, and p53 levels in a dose-dependent manner . At a concentration of 1.5 μM, NiCur can decrease H3K27ac levels; similarly, at 1.5 μM, NiCur can restore cell proliferation capacity. In intestinal epithelial cells, NiCur downregulates Dox-mediated p53 activation but does not affect H2A.X S139p levels. NiCur can modulate gene regulatory switches, thereby reprogramming the chromatin landscape, and can block CBP HAT activity .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Histone Acetyltransferase,PARP,Apoptosis,Epigenetic Reader Domain,Caspase