Neuropeptide Y (18-36)

SKU: orb3053997

Description

Neuropeptide Y (18-36) (porcine) is a competitive neuropeptide Y (NPY) cardiac receptor antagonist.

Key Properties

• CAS Number: 114495-97-5
• MW: 3000.5
• Purity: >98% (HPLC)
• Formula: C₁₃₄H₂₀₇N₄₁O₃₆S
• Solubility: DMSO : ≥ 100 mg/mL (40.70 mM; )

Bioactivity

• In Vitro:
  Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to rat cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM. Neuropeptide Y (18-36) (porcine) (1 μM) shifts the inhibitory adenylate cyclase activity dose-response curve of NPY to the right in a parallel fashion. Neuropeptide Y (18-36) (porcine) (1 μM) completely abolishes the effect of NPY (10 nM) that alone caused 80% of the maximum inhibition of adenylate cyclase activity.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only