Necrostatin 2 racemate

SKU: orb1220416

Description

Necrostatin 2 racemate is an potent and specific inhibitor of RIPK1.

Key Properties

• CAS Number: 852391-15-2
• MW: 277.71
• Purity: >98% (HPLC)
• Formula: C₁₃H₁₂ClN₃O₂
• SMILES: CN1C(=O)NC(Cc2c[nH]c3c(Cl)cccc23)C1=O
• Target: RIP kinase
• Solubility: DMSO:50 mg/mL (180.04 mM)

Bioactivity

• In Vivo:
  Necrostatin 2 racemate (Nec-1S) (6 mg/kg; i. v. ; once) protects against TNF-induced systemic inflammatory response syndrome (SIRS) without sensitization effect. Animal model: Female C57BL/6J WT mice, SIRS model. Dosage: 0.6 mg/kg or 6 mg/kg. Administration: Intravenous injection, once. Result: Showed protective effect at 6 mg/kg.
• In Vitro:
  Necrostatin 2 racemate (Nec-1S) (1-100 μM; 1 h) potently inhibits RIPK1 autophosphorylation in a dose-dependent manner.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Necrostatin-2 racemate

Quick Database Links

Gene Symbol

RIP kinase