Nafamostat mesylate

SKU: orb1305551

Description

Nafamostat mesylate

Research Area

Cell Biology, Infectious Disease & Virology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 82956-11-4
• MW: 539.58
• Purity: 99.70%
• Formula: C₁₉H₁₇N₅O₂·2CH₄O₃S
• SMILES: CS(O)(=O)=O.CS(O)(=O)=O.NC(=N)Nc1ccc(cc1)C(=O)Oc1ccc2cc(ccc2c1)C(N)=N
• Target: Apoptosis,NF-κB,SARS-CoV,Serine Protease,TNF,Anti-infection
• Solubility: DMSO:121 mg/mL (224.25 mM);H2O:54 mg/mL (100.08 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.41 mM)

Bioactivity

• In Vivo:
  Nafamostat mesilate significantly inhibit the release of platelet β-thromboglobulin (βTG) an the release of elastase from neutrophils. It also prevent the formation of complexes betwee the C1 inhibitor and both prekallikrein and FXIIa. furthermore , Nafamostat mesilate inhibit the extrinsic pathway activity mediated b the TF-F.VIIa complex, leading to the production of F.Xa, with an IC50 value of 0.1 μM.
• In Vitro:
  Nafamostat Mesylate inhibits bot the activation of NF-κB and apoptosis induced by gemcitabine and restrain the growth of pancreatic tumors. At a dosage of 10 mg/kg, it exhibits an inhibitory effect on wounds induced by trypsin. furthermore , a the same dosage, Nafamostat Mesylate suppresses tryptase activity in mouse skin.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Serine Protease, Ser/Thr Protease, Serine endopeptidases, Serine kinase, threoninkinase, Threonine proteases, threonin kinase, SerineProtease, Serinekinase, Serine proteases, SARS-CoV, SARSCoV, SARS coronavirus, FUT175, FUT-175, FUT 175, Inhibitor, Nafamostat, Nafamostat mesylate, Nafamostat Mesylate, inhibit, Apoptosis

Compound Identifiers

PubChem CID

5311180