Nafamostat mesylate

SKU: orb1305551

Description

Nafamostat mesylate

Research Area

Neuroscience

Key Properties

• CAS Number: 82956-11-4
• MW: 347.38 ∙ 192.21
• Purity: >98%
• Formula: C₁₉H₁₇N₅O₂ ∙ 2CH₄O₃S
• SMILES: CS(O)(=O)=O.CS(O)(=O)=O.NC(=N)Nc1ccc(cc1)C(=O)Oc1ccc2cc(ccc2c1)C(N)=N
• Target: Protease
• Solubility: Soluble in Water (up to 25 mg/ml).

Bioactivity

• In Vivo:
  Nafamostat mesilate significantly inhibits the release of platelet β-thromboglobulin (βTG) and the release of elastase from neutrophils. It also prevents the formation of complexes between the C1 inhibitor and both prekallikrein and FXIIa. Furthermore, Nafamostat mesilate inhibits the extrinsic pathway activity mediated by the TF-F.VIIa complex, leading to the production of F.Xa, with an IC50 value of 0.1 μM.
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• In Vitro:
  Nafamostat Mesylate inhibits both the activation of NF-κB and apoptosis induced by gemcitabine and restrains the growth of pancreatic tumors. At a dosage of 10 mg/kg, it exhibits an inhibitory effect on wounds induced by trypsin. Furthermore, at the same dosage, Nafamostat Mesylate suppresses tryptase activity in mouse skin.
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Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Futhan; FUT-175

Compound Identifiers

PubChem CID

5311180