MYLIP (C) Antibody, Rabbit Polyclonal

SKU: orb66979

Description

Rabbit polyclonal to MYLIP.Myosin regulatory light chain interacting protein (MYLIP) is also known as inducible degrader of theLDL-receptor (IDOL), which is an E3 ubiquitin-protein ligase that mediates ubiquitination andsubsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR andLRP8. Proteasomal degradation of MRLC leads to the inhibition of neurite outgrowth in the presenceof NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) andreducing CNPY2-stimulated neurite outgrowth. MYLIP also acts as a sterol-dependent inhibitor ofcellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

Research Area

Epigenetics

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:1000-1:5000
• Reactivity: Human, Mouse

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: C-terminal region of human MYLIP
• Molecular Weight: 50
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-MYLIP antibody,anti-E3 ubiquitinprotein ligase MYLIP antibody,anti-Inducible degrader of the LDLreceptor antibody,anti-Idol antibody,anti-IDOL antibody,anti-Myosin regulatory light chain interacting protein antibody,anti-MIR antibody,anti-BZF1 antibody,anti-BM023 antibody,anti-PP5242 antibody

Western blot analysis of total cell extracts from human MCF7(Lane1) and mouse brain(Lane2) using MYLIP antibody

Quick Database Links

UniProt

Q8WY64