MS023

SKU: orb1300363

Description

MS023

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1831110-54-3
• MW: 287.4
• Purity: 99.28%
• Formula: C₁₇H₂₅N₃O
• SMILES: CC(C)Oc1ccc(cc1)-c1c[nH]cc1CN(C)CCN
• Target: Histone Methyltransferase
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:245 mg/mL (852.47 mM);Ethanol:53 mg/mL (184.41 mM)

Bioactivity

• Target IC50:
  PRMT8:5 nM|PRMT4:83 nM|PRMT3:119 nM|PRMT1:30 nM|PRMT6:4 nM
• In Vitro:
  MS023 potently reduces cellular levels of H4R3me2a in MCF7 and HEK293 cells by inhibiting PRMT1/6 methyltransferase activity with IC50 of 9 nM and 56 nM, respectively. MS023 also inhibits cell growth and potentially induces growth arrest and flattening morphology at low concentrations.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, MS 023, MS023, MS-023, HistoneMethyltransferase, Histone Methyltransferase, PRMT8, PRMT3, PRMT1, PRMT4, PRMT6

Compound Identifiers

PubChem CID

92136227