MPP+ iodide

SKU: orb1298313

Description

MPP+ iodide is a neurotoxic metabolite used to model Parkinson's disease, selectively destroying dopaminergic neurons via DAT externalization while internalizing SERT in serotonergic neurons. It is widely applied in neuroscience research to study neurodegenerative mechanisms, including autophagic cell death in vitro models like SH-SY5Y cells.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 36913-39-0
• MW: 297.13
• Purity: 99.96% (May vary between batches)
• Formula: C₁₂H₁₂IN
• SMILES: [I-].C=1C=CC(=CC1)C=2C=C[N+](=CC2)C
• Target: Mitochondrial Metabolism,Autophagy
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.46 mM);H2O:100 mg/mL (336.55 mM);DMSO:135 mg/mL (454.35 mM)

Bioactivity

• In Vivo:
  METHODS: To test for acute toxicity to embryonic or neonatal mice, MPP+ iodide (8.6-34.2 mg/kg) was injected intraperitoneally into pregnant or neonatal mice. RESULTS: Neurotoxicity induced by a single injection of MPP+ iodide was transient and recoverable in embryonic and neonatal mice. In contrast, no significant changes in MAO-A and MAO-B expression levels were observed in MPP+ iodide-treated mice.
• In Vitro:
  METHODS: Human neuroblastoma cells SH-SY5Y were treated with MPP+ iodide (1-4 mM) for 12-48 h, and cell viability was detected using CCK-8 Assay.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, MPP+, MPP+ iodide, MPP+ Iodide, neurotoxic, neurons, Mitochondrial Metabolism, MitochondrialMetabolism, Autophagy, complex, chain, dopaminergic, respiratory

Compound Identifiers

PubChem CID

10924457