MPP+ iodide

SKU: orb1218096

Description

MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells.

Key Properties

• CAS Number: 36913-39-0
• MW: 297.13
• Purity: >98% (HPLC)
• Formula: C₁₂H₁₂IN
• SMILES: C[n+](cc1)ccc1-c1ccccc1.[I-]
• Target: Autophagy
• Solubility: DMSO:62.5 mg/mL (210.34 mM; Need ultrasonic);Water:100 mg/mL (336.54 mM; Need ultrasonic)

Bioactivity

• In Vitro:
  Cell Viability Assay Cell line: SH-SY5Y cells. Concentration: 1, 2, 3 mM. Incubation time: 24 hours. Result: SH-SY5Y cells were treated with MPP+, mimicking the progress of dopaminergic neurons loss in PD; Reduced cell viability in both dose-dependent (1, 2, 3 mM for 24 h) and time dependent (1 mM) manner.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Autophagy