MLCK inhibitor peptide 18

SKU: orb1679457

Description

This cell-permeable small molecule is a potent and selective competitive inhibitor of myosin light chain kinase (MLCK), exhibiting an IC50 of 50 nM. It shows >4000-fold selectivity over CaM kinase II and no activity against PKA, making it a valuable tool for investigating smooth muscle contraction, endothelial barrier function, and cell motility in both cellular and animal models.

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• Target: Myosin,Autophagy,CaMK
• CAS Number: 224579-74-2
• MW: 1324.64
• Formula: C₆₀H₁₀₅N₂₃O₁₁
• SMILES: [C@@H](CC1=CC=C(O)C=C1)(NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@H](CCCNC(=N)N)N)=O)CCCCN)=O)CCCCN)=O)=O)CCCCN)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

10102940