ML251

SKU: orb1940856

Description

ML251 is a potent novel nanomolar inhibitor of T. brucei and T. cruzi phosphofructokinase. ML251 inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite.(In Vitro):ML251 produces modest dose-dependent toxicity.

Key Properties

• CAS Number: 1486482-16-9
• MW: 426.27
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₃Cl₂N₃O₄S
• SMILES: O=C(Cc(cc1)cc(Cl)c1Cl)Nc(cc1)ccc1S(Nc1nocc1)(=O)=O
• Target: Glucokinase
• Solubility: In Vitro: DMSO : 250 mg/mL (586.48 mM)

Bioactivity

• In Vitro:
  ML251 (T. brucei; 0~33.3 μg/mL) produces modest dose-dependent toxicity. Cell Cytotoxicity Assay Cell line: T. brucei Concentration: 0~33.3 μg/mL Incubation time: Result: Dose-dependent reduction of cell viability.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ML251?

Quick Database Links

Gene Symbol

Glucokinase