ML251

SKU: orb1685726

Description

ML251 is a novel, nanomolar-range inhibitor targeting phosphofructokinase in Trypanosoma brucei (IC50=0.37 µM) and Trypanosoma cruzi (IC50=0.13 µM). This compound is a valuable research tool for studying parasite metabolism and glycolysis in both in vitro and in vivo experimental models of trypanosomiasis.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 1486482-16-9
• MW: 426.27
• Purity: 99.87%
• Formula: C₁₇H₁₃Cl₂N₃O₄S
• SMILES: Clc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2ccon2)cc1Cl
• Target: Parasite,Glucokinase
• Solubility: DMSO:50 mg/mL (117.3 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (5.86 mM)

Bioactivity

• Target IC50:
  PFK (T. cruzi):0.13 μM|PFK (T. b. brucei):0.37 μM
• In Vitro:
  ML251 produces modest dose-dependent toxicity.
• Cell Research:
  The cell cytotoxicity assay of ML251 (0~33.3 μg/mL) in T. brucei cell shows dose-dependent reduction of cell viability.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cruzi, brucei, inhibit, MRC-5, Parasite, nanomolar, ML251, ML-251, ML 251, Inhibitor, PFK

Compound Identifiers

PubChem CID

53255421