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MK-571

SKU: orb1299457

Description

MK 571

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number115104-28-4
MW537.1
Purity>98%
FormulaC26H26ClN2O3S2 · Na
SMILESC(=C/C1=CC(C(SCCC(N(C)C)=O)SCCC(O)=O)=CC=C1)\C2=NC3=C(C=C2)C=CC(Cl)=C3
TargetLeukotriene receptor
SolubilitySoluble in DMSO (up to 50 mg/ml).

Bioactivity

Target IC50
LTD4:2.1 nM (Ki, in human lung)|LTD4:0.22 nM (Ki, in guinea pig lung)|LTD4:10.5 (pA2, in guinea pig ileum)|LTE4:10.4 (pA2, in guinea pig ileum)
In Vivo
MK-571 effectively blocks LTD4 activation of recombinant human and murine CysLT1 receptors1,4 but is ineffective at blocking LTC4 or LTD4 activation of the recombinant human or murine CysLT2 receptors.

Storage & Handling

StorageRT
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

L-660711

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

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5 mg
$ 190.00
25 mg
$ 400.00
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