MK 571

SKU: orb1299457

Description

MK 571

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 115104-28-4
• MW: 515.09
• Purity: 99.65%
• Formula: C₂₆H₂₇ClN₂O₃S₂
• SMILES: C(=C/C1=CC(C(SCCC(N(C)C)=O)SCCC(O)=O)=CC=C1)\C2=NC3=C(C=C2)C=CC(Cl)=C3
• Target: P-gp,LPL Receptor,Leukotriene Receptor,LTR
• Solubility: DMSO:9 mg/mL (17.47 mM)

Bioactivity

• Target IC50:
  LTD4:2.1 nM (Ki, in human lung)|LTD4:0.22 nM (Ki, in guinea pig lung)|LTD4:10.5 (pA2, in guinea pig ileum)|LTE4:10.4 (pA2, in guinea pig ileum)
• In Vivo:
  MK-571 effectively blocks LTD4 activation of recombinant human and murine CysLT1 receptors1,4 but is ineffective at blocking LTC4 or LTD4 activation of the recombinant human or murine CysLT2 receptors.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CysLTR1, L660711, L-660711, MK571, MK-571, MK 571, L 660711

Compound Identifiers

PubChem CID

5281888