Miglustat hydrochloride

SKU: orb1940040

Description

Miglustat hydrochloride is an inhibitor of glucosylceramide synthase and can be used for studies about Type I Gaucher disease. (In Vivo):Consumption of a standard high-fat breakfast within 30 minutes before administration of Miglustat hydrochloride significantly reduced peak exposure but did not significantly affect the extent of systemic exposure to Miglustat hydrochloride. The Cmax decreased by 36% on average following administration with food. AUC showed a modest (14%) decrease with food, but the 90% confidence interval was within the acceptance limit of 80% to 125%. Tmax was prolonged from 2.5 (1.0-4.0) hours in the fasted state to 4.5 (1.5-8.0) hours in the fed state, whereas the apparent terminal half-life was approximately 8 hours and not affected by food.

Key Properties

• CAS Number: 210110-90-0
• MW: 255.74
• Purity: >98% (HPLC)
• Formula: C₁₀H₂₂ClNO₄
• SMILES: Cl.CCCCN1CC(O)[C@@H](O)C(O)C1CO
• Target: Transferase
• Solubility: In Vitro: DMSO : 65 mg/mL (254.16 mM)

Bioactivity

• In Vivo:
  Mi. Animal model: NPC1 / mice. Dosage: 0.2 mg/kg. Administration: Oral administration; once. Result: Was able to rescue synaptic plasticity deficits, to restore ERKs activation and to counteract hyperexcitability.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NB-DNJ hydrochloride | OGT918 hydrochloride | N-Butyldeoxynojirimycin hydrochloride

Quick Database Links

Gene Symbol

Transferase