Miglustat HCl (N-Butyldeoxynojirimycin)

SKU: orb1296169

Description

Miglustat hydrochloride is a glucosylceramide synthase inhibitor used to study Type I Gaucher disease. It is employed in both in vitro and in vivo research models to investigate substrate reduction therapy and the pathophysiology of glycosphingolipid storage disorders.

Research Area

Neuroscience

Key Properties

• CAS Number: 210110-90-0
• MW: 255.74
• Purity: >98%
• Formula: C₁₀H₂₁NO₄ HCl
• SMILES: Cl.CCCCN1CC(O)C(O)C(O)C1CO
• Target: Glycosylation
• Solubility: Soluble in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml).

Bioactivity

• In Vivo:
  Consumption of a standard high-fat breakfast within 30 minutes before administration of Miglustat hydrochloride significantly reduced peak exposure but did not significantly affect the extent of systemic exposure to Miglustat hydrochloride. The Cmax decreased by 36% on average following administration with food. AUC showed a modest (14%) decrease with food, but the 90% confidence interval was within the acceptance limit of 80% to 125%. Tmax was prolonged from 2.5 (1.0-4.0) hours in the fasted state to 4.5 (1.5-8.0) hours in the fed state, whereas the apparent terminal half-life was approximately 8 hours and not affected by food.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NB-DNJ

Compound Identifiers

PubChem CID

53395419