Miglustat hydrochloride

SKU: orb1296169

Description

Miglustat hydrochloride is a glucosylceramide synthase inhibitor used to study Type I Gaucher disease. It is employed in both in vitro and in vivo research models to investigate substrate reduction therapy and the pathophysiology of glycosphingolipid storage disorders.

Research Area

Metabolism Research

Key Properties

• CAS Number: 210110-90-0
• MW: 255.74
• Purity: 99.85% (May vary between batches)
• Formula: C₁₀H₂₂ClNO₄
• SMILES: Cl.CCCCN1CC(O)C(O)C(O)C1CO
• Target: Transferase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (9.78 mM);DMSO:60 mg/mL (234.61 mM);H2O:34 mg/mL (132.95 mM)

Bioactivity

• In Vivo:
  Consumption of a standard high-fat breakfast within 30 minutes before administration of Miglustat hydrochloride significantly reduced peak exposure but did not significantly affect the extent of systemic exposure to Miglustat hydrochloride. The Cmax decreased by 36% on average following administration with food. AUC showed a modest (14%) decrease with food, but the 90% confidence interval was within the acceptance limit of 80% to 125%. Tmax was prolonged from 2.5 (1.0-4.0) hours in the fasted state to 4.5 (1.5-8.0) hours in the fed state, whereas the apparent terminal half-life was approximately 8 hours and not affected by food.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ceramide glucosyltransferase, glucosylceramide synthase, Glucosylceramide Synthase (GCS), Inhibitor, inhibit, OGT 918, OGT 918 Hydrochloride, OGT918, OGT-918, OGT918 Hydrochloride, OGT918 hydrochloride, OGT-918 Hydrochloride, oral, Miglustat, Miglustat hydrochloride, Miglustat Hydrochloride, NB-DNJ, NB-DNJ hydrochloride, NB-DNJ Hydrochloride, N-Butyldeoxynojirimycin, N-Butyldeoxynojirimycin Hydrochloride, N-Butyldeoxynojirimycin hydrochloride, type I gaucher disease

Compound Identifiers

PubChem CID

53395419