Metyrapone

SKU: orb1310750

Description

Metyrapone (NSC-25265) is a potent and selective inhibitor of steroid 11β-hydroxylase, the enzyme encoded by CYP11B1. It is widely used in both clinical diagnostics for assessing hypothalamic-pituitary-adrenal axis function in Cushing's syndrome and in biomedical research to modulate corticosteroid levels in vitro and in vivo.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 54-36-4
• MW: 226.27
• Purity: >98%
• Formula: C₁₄H₁₄N₂O
• SMILES: CC(C)(C(=O)c1cccnc1)c1cccnc1
• Target: Cytochrome/MDR
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).

Bioactivity

• Target IC50:
  11β-HSD1:30 μM(Ki)

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cytochrome P450, CYPs, Cushing's syndrome, depression, Autophagy, behavior, Camphor 5-monooxygenase, aldosterone, 11β-hydroxylase, 11β-HSD1, inhibit, NSC 25265, NSC25265, NSC-25265, Metyrapone, Inhibitor, Endogenous Metabolite, emotion, water maze, Sprague-Dawley rats, Su4885, Su-4885, Su 4885

Compound Identifiers

PubChem CID

4174