Metyrapone

SKU: orb1224733

Description

Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1.(In Vitro):Metyrapone (100 μM; 2 h) hyperactivates autophagy in HepG2, and delays the activation of apoptosis at severe endoplasmic reticulum (ER) stress.(In Vivo):Metyrapone (25 or 50 mg/kg; SC, single dosage) decreases the stress-induced increase in plasma corticosterone levels, significantly impairs acquisition performance at high dosage, and increases open arm activity at low dosage.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 54-36-4
• MW: 226.27
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₄N₂O
• SMILES: CC(C1=CC=CN=C1)(C)C(C2=CC=CN=C2)=O
• Target: Camphor 5-monooxygenase
• Solubility: sparingly soluble in Water

Bioactivity

• In Vivo:
  Animal model: Male Sprague-Dawley rats (n = 179; 270-300g). Dosage: 25 or 50 mg/kg (in a volume of 2.0 mL/kg). Administration: SC, single dosage. Result: Dose-dependently decreased the stress-induced increase in plasma corticosterone levels in the water maze test; the high level dose significantly impaired acquisition performance in the water maze and decreased fear-induced immobility; the lower dose increased open arm activity.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 25265 | SU 4885

Quick Database Links

Gene Symbol

Camphor 5-monooxygenase