Methyl pyropheophorbide-a

SKU: orb1696015

Description

Methyl pyropheophorbide-a (MPPa) is a chlorophyll-derived chlorin photosensitizer used in cancer photodynamic therapy (PDT) research. It exhibits photodynamic activity, inducing apoptosis and inhibiting tumor growth in both in vitro and in vivo experimental models.

Research Area

Cell Biology

Key Properties

• CAS Number: 6453-67-4
• MW: 548.67
• Purity: 98.17% (May vary between batches)
• Formula: C₃₄H₃₆N₄O₃
• SMILES: CCc1c(C)c2cc3[nH]c(cc4nc([C@@H](CCC(=O)OC)[C@@H]4C)c4CC(=O)c5c(C)c(cc1n2)[nH]c45)c(C)c3C=C
• Target: Photosensitizer,Apoptosis
• Solubility: DMSO:1 mg/mL (1.82 mM)

Bioactivity

• In Vivo:
  In male BALB/c nude mice (6-8 weeks old, 16-20 g) bearing PC-3M tumors, Methyl pyropheophorbide-a (15 mg/kg; tail vein injection and topical injection) resulted in tumor volume and weight inhibition rates of 46.78% and 41.84% in the tail vein injection group, respectively, and 78.66% and 72.07% in the topical injection group, respectively.
• In Vitro:
  In PC-3M cells, after treatment with Methyl pyropheophorbide-a (2 μM; 12 h) under LC75 conditions (2 μM + 55.6 kJ/m²), the apoptosis rates were approximately 0.27%, 6.15%, 20.49%, 50.76%, 65.39%, 64.92%, and 64.37% at 1, 3, 6, 12, 18, and 24 hours post-treatment, respectively.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, Methyl pyropheophorbide a, Methyl pyropheophorbidea, Methyl pyropheophorbide-a, NSC267052, NSC-267052, NSC 267052, MPPa, MPPa (Methyl pyropheophorbide-a), Pyropheophorbide-a methyl ester, Pyropheophorbidea

Compound Identifiers

PubChem CID

98173843