Menin-MLL inhibitor 21

SKU: orb3027221

Description

Menin-mll inhibitor 21 is a selective, oral and irreversible Menin inhibitor. Menin-MLL inhibitor 21 promotes selective proliferation of β cells and improvement of β cell function in human islet cultures in vitro. Menin-MLL inhibitor 21 enhances glycemic control in animal models of diabetes. Menin-MLL inhibitor 21 induced a dose-dependent increase in insulin secretion that was augmented by a GLP-1 receptor agonist (RA).

Research Area

Epigenetics & Chromatin

Images & Validation

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Key Properties

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CAS Number	2448172-22-1
MW	566.65
Purity	99.95%
Formula	C₃₁H₃₄N₈O₃
SMILES	N(C(=O)C1=CC(CN2C[C@H](NC(C=C)=O)CCC2)=CC=N1)C3=CC=C(C4=CC5=C(N=CN=C5N4)N6CCOCC6)C=C3
Target	Epigenetic Reader Domain,Histone Methyltransferase
Solubility	DMSO:50 mg/mL (88.24 mM)

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Menin-MLL, Menin-MLL inhibitor 21, Histone Methyltransferase, HistoneMethyltransferase, Icovamenib, BMF 219, BMF219, BMF-219

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Gene Symbol

Epigenetic Reader Domain,Histone Methyltransferase

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