MA-0204

SKU: orb1308076

Description

MA-0204

Research Area

Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 2095128-17-7
• MW: 476.49
• Purity: 97.80% (May vary between batches)
• Formula: C₂₅H₂₇F₃N₂O₄
• SMILES: C[C@H](CCCOc1ccccc1Cn1c(C)cnc1-c1ccc(OC(F)(F)F)cc1)CC(O)=O
• Target: PPAR
• Solubility: DMSO:40 mg/mL (83.95 mM);10% DMSO+90% Corn Oil:2 mg/mL (4.2 mM)

Bioactivity

• Target IC50:
  PPARδ:0.4 nM (EC50)(in human)|PPARδ:10 nM (EC50)(in rat)|PPARδ:7.9 nM (EC50)(in mouse)
• In Vivo:
  In the muscle, PPARδ (30, 100 mg/kg) enhances target gene transcription.
• In Vitro:
  MA-0204 is >10,000-fold selective for activating PPARδ over PPARα and PPARγ receptors. At concentrations of 1.2-12 nM, MA-0204 enhances fatty acid oxidation in muscle myoblasts from DMD patients in mice, shows high protein binding in mouse plasma, exhibits good permeability, and has low potential for efflux. [C.]
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, MA0204, MA-0204, MA 0204, Inhibitor, PPARδ, Peroxisome proliferator-activated receptors, PPAR

Compound Identifiers

PubChem CID

126752361