MA-0204

SKU: orb1218475

Description

MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively). It is a potential treatment for Duchene Muscular Dystrophy (DMD).

Key Properties

• CAS Number: 2095128-17-7
• MW: 476.49
• Purity: >98% (HPLC)
• Formula: C₂₅H₂₇F₃N₂O₄
• SMILES: C[C@H](CCCOc1c(Cn2c(-c(cc3)ccc3OC(F)(F)F)ncc2C)cccc1)CC(O)=O
• Target: PPAR
• Solubility: DMSO:40 mg/mL (83.95 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  PPARδ (30, 100 mg/kg) increases target gene transcription in the muscle.
• In Vitro:
  MA-0204 is >10, 000-fold selective for activation of PPARδ over PPARα and PPARγ receptors. MA-0204 exhibits high protein binding to mouse plasma, good permeability and low potential for efflux. C. MA-0204 (1.2-12 nM) improves fatty acid oxidation in DMD patient muscle myoblasts mice. MA-0204 (0.04-40 nM) engages target gene expression in DMD patient muscle myoblasts.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PPAR