m-PEG7-Br

SKU: orb1307377

Description

m-PEG7-Br is a bromo-terminated polyethylene glycol linker used in constructing PROTAC molecules. Its hydrophilic PEG spacer enhances solubility and pharmacokinetics, making it valuable for developing degraders for both in vitro and in vivo target validation studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 104518-25-4
• MW: 403.31
• Purity: ≥98% (May vary between batches)
• Formula: C₁₅H₃₁BrO₇
• SMILES: COCCOCCOCCOCCOCCOCCOCCBr
• Target: PROTAC Linker

Bioactivity

• In Vitro:
  PROTACs utilize two distinct ligands linked together: one binds to an E3 ubiquitin ligase and the other to the target protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs enable the selective degradation of target proteins .

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, m-PEG7-Br, mPEG7Br, m-PEG-7-Br, m PEG7 Br, Inhibitor, PEGs, PROTACLinker, PROTAC Linkers, PROTAC Linker

Compound Identifiers

PubChem CID

122715420