M-31850

SKU: orb1298523

Description

M-31850

Research Area

Metabolism Research

Key Properties

• CAS Number: 281224-40-6
• MW: 463.48
• Purity: 99.71% (May vary between batches)
• Formula: C₂₈H₂₁N₃O₄
• SMILES: O=C1N(CCNCCN2C(=O)c3cccc4cccc(C2=O)c34)C(=O)c2cccc3cccc1c23
• Target: glycosidase,Others
• Solubility: DMSO:5 mg/mL (10.79 mM)

Bioactivity

• Target IC50:
  OfHex2:2.5 μM (Ki)|HexB (human):3.1 µM (IC50)|HexA (human):6.0 µM (IC50)
• In Vitro:
  M-31850 increases the half-life of the mutant Hex A from Adult forms of Tay-Sachs (ATSD) cells more than two-fold at 44° C, relative to the enzyme heated in the presence of DMSO. M-31850 acts as a classic competitive inhibitor of Hex (Km increases and Vmax is unaffected by increasing amounts of M-31850), with a Ki of 0.8 μM.M-31850 shows some activity towards Jack Bean Hex (JBHex) and bacterial Hex from Streptomyces plicatus (SpHex) (IC50 of 280 M and >500 M for JBHex and SpHex, respectively)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

β-hexosaminidase, β-hexosaminidase (Hex), Inhibitor, non-carbohydrate, inhibit, OfHex2, M 31850, M31850, M-31850, 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2,2'-(iminodi-2,1-ethanediyl)bis-

Compound Identifiers

PubChem CID

342139