LY310762

SKU: orb1305163

Description

LY310762 is a selective small molecule antagonist of the serotonin 5-HT1D receptor, exhibiting a binding affinity (Ki) of 249 nM. It is a valuable research tool for investigating the role of this receptor subtype in neurological pathways and related disorders through in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 192927-92-7
• MW: 430.94
• Purity: 99.80% (May vary between batches)
• Formula: C₂₄H₂₇FN₂O₂·HCl
• SMILES: Cl.CC1(C)C(=O)N(CCN2CCC(CC2)C(=O)c2ccc(F)cc2)c2ccccc12
• Target: 5-HT Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.32 mM);H2O:4.31 mg/mL (10 mM);DMSO:43.1 mg/mL (100.01 mM)

Bioactivity

• Target IC50:
  5-HT1D:249 nM(Ki)
• In Vivo:
  LY310762 enhances potassium-induced [3H] 5-HT efflux from guinea pig cortical slices, with an EC50 of 30 nM. The maximal enhancement of potassium-induced [3H]5-HT efflux by LY310762 is approximately 40%. LY310762 exhibits a higher affinity for the guinea pig 5-HT1D receptor than for the 5-HT1B receptor.
• In Vitro:
  Following treatment with LY310762, the levels of 5-HT in animals treated with fluoxetine increased from 312±43% to a peak of 683%. In the control group, the 5-HT levels remained constant at 250%. Compared to animals that received a control vehicle injection, systemic administration of 10 mg/kg i.p. LY310762 significantly enhanced the response of 5-HT to 20 mg/kg i.p. fluoxetine. When administered alone, LY310762 notably raised the baseline levels of 5-HT above the vehicle control, achieving a maximum value of 258% compared to the pre-injection control group.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5HTReceptor, 5-HT1D, 5-HT Receptor, 5HT Receptor, LY310762, LY-310762, LY310762 HCl, LY 310762

Compound Identifiers

PubChem CID

11957576