LY310762

SKU: orb1222560

Description

LY310762 is a 5-HT1D antagonist with Ki of 249 nM, having a weaker affinity for 5-HT1B receptor.

Key Properties

• CAS Number: 192927-92-7
• MW: 430.94
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₇FN₂O₂·HCl
• SMILES: Cl.CC1(C)C(=O)N(CCN2CCC(CC2)C(=O)c2ccc(F)cc2)c2ccccc12
• Target: Antioxidant
• Solubility: DMSO : ≥ 44 mg/mL; 102.10 mM

Bioactivity

• In Vivo:
  LY310762 (10 mg/kg; i.p.; single) significantly increases the extracellular 5-HT concentration produced by Fluoxetine (selective serotonin re-uptake inhibitor) In vivo. LY310762 (1 mg/kg; i. v. ; single) abolishes 5-HT vasodilator effects in phenylephrine-infusion rats model. Animal model: Dunkin Hartley guinea pigs (female; 350-400 g, Harlan). Dosage: 10 mg/kg. Administration: Intraperitoneal injection; single. Result: Produced a further significant enhancement in the 5-HT response to fluoxetine. Animal model: Male Wistar rats (270-330 g; phenylephrine-infusion rats model). Dosage: 1 mg/kg. Administration: Intravenous injection; single. Result: Completely abolished 5-HT vasodilator effects.
• In Vitro:
  LY310762 (0.01-1 μM) shows potentiation of potassium-induced [3H]5-HT outflow from guinea pig cortical slices with an EC50 value of 31 nM. LY310762 (10 μM) significantly but not completely blocks the extent of sumatriptan-induced decrease in EPSCs (excitatory postsynaptic potential).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LY310762 | LY 310762 | LY-310762

Quick Database Links

Gene Symbol

Antioxidant