LY2183240

SKU: orb1308103

Description

LY2183240 is a potent dual-action inhibitor, blocking anandamide cellular uptake with high affinity (IC50 = 270 pM) and inhibiting FAAH enzymatic activity (IC50 = 12.4 nM). This compound is a valuable research tool for studying the endocannabinoid system in both in vitro and in vivo models.

Research Area

Neuroscience

Key Properties

• CAS Number: 874902-19-9
• MW: 307.35
• Purity: >98%
• Formula: C₁₇H₁₇N₅O
• SMILES: CN(C)C(=O)n1nnnc1Cc1ccc(cc1)-c1ccccc1
• Target: Serine hydrolase
• Solubility: Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 15 mg/ml).

Bioactivity

• Target IC50:
  FAAH:12.4 nM
• In Vitro:
  LY2183240 increases brain anandamide concentration and exerts antinociceptive effects in the formalin model of pain, anandamide uptake Following i.p. administration in rats.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anandamide, Autophagy, brain, hydrolases, FAAH, Fatty acid amide hydrolase, LY2183240, LY-2183240, LY 2183240, Inhibitor, inhibit, serine, uptake, transport

Compound Identifiers

PubChem CID

11507802