LY2183240

SKU: orb1217549

Description

LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). LY2183240 is a novel and highly effective blocker of anandamide uptake (IC50 = 270 pM).

Key Properties

• CAS Number: 874902-19-9
• MW: 307.35
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₇N₅O
• SMILES: O=C(N(C)C)N1N=NN=C1CC(C=C2)=CC=C2C3=CC=CC=C3
• Target: Autophagy
• Solubility: DMSO:50 mg/mL (162.68 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  LY2183240 (3-30 mg/kg; i.p.) dose-dependently attenuates formalin-induced paw-licking pain behavior in the formalin model of persistent pain mechanisms. Animal model: Male Sprague-Dawley rats (Formalin Pain Model). Dosage: 3, 10, 30 mg/kg. Administration: i.p. Result: Dose-dependently attenuated formalin-induced paw-licking pain behavior in the formalin model of persistent pain mechanisms.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Autophagy