LY2119620

SKU: orb1300645

Description

LY2119620

Research Area

Neuroscience

Key Properties

• CAS Number: 886047-22-9
• MW: 437.94
• Purity: 99.70%
• Formula: C₁₉H₂₄ClN₅O₃S
• SMILES: CN1CCN(CC1)C(=O)COc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl
• Target: AChR
• Solubility: DMSO:50 mg/mL (114.17 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.57 mM);Ethanol:10 mg/mL (22.83 mM)

Bioactivity

• In Vitro:
  LY2119620 displays modest allosteric agonism and positively modulate the functional G protein–signaling ability of an agonist a the M2/M4 receptor subtypes by placin the M2 and M4 receptors into an active G protein–bound state. LY2119620 enhance the potency of three muscarinic acetylcholine receptor agonists, ACh, Oxo-M and iperoxo. [3H]LY2119620 can be used as a probe fo the human M(2) and M(4) muscarinic receptor allosteric binding sites.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

mAChR, M2 mAChR, M4 mAChR, LY 2119620, LY2119620, LY-2119620, Inhibitor, Muscarinic acetylcholine receptor, inhibit

Compound Identifiers

PubChem CID

57664406