LY2119620

SKU: orb1223011

Description

LY2119620 is a positive allosteric modulator of the M2 and M4 muscarinic acetylcholine receptors (mAChRs).

Key Properties

• CAS Number: 886047-22-9
• MW: 437.94
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₄ClN₅O₃S
• SMILES: CN1CCN(CC1)C(=O)COc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl
• Target: M2 mAChR|M4 mAChR
• Solubility: DMSO : 67.5 mg/mL. 154.13 mM; H2O : < 0.1 mg/mL

Bioactivity

• In Vitro:
  LY2119620 shows a modest allosteric agonism of 23.2±2.18% and 16.8±5.01% at the M2 and M4 receptors, respectively. Minimal allosteric agonism (< 20%) is observed for LY2119620 at the M1, M3, and M5 receptors. The variable KB of LY2119620 for the allosteric binding site on the unoccupied receptor is found to be consistently about 1.9 to 3.4 μM. Results show a Bmax increase at the M2 receptor from 793±1.95 fmol/mg to 2850±162 fmol/mg upon addition of 10 μM LY2119620, and about a 5-fold increase in Bmax at the M4 receptor, 284±18.3 fmol/mg to 1340±42.2 fmol/mg.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LY2119620 | LY 2119620 | LY-2119620

Quick Database Links

Gene Symbol

M2 mAChR|M4 mAChR