LC3-mHTT-IN-AN1

SKU: orb1299237

Description

LC3-mHTT-IN-AN1

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 486443-73-6
• MW: 411.04
• Purity: 97.26%
• Formula: C₁₅H₉Br₂NO₃
• SMILES: Oc1cc(\C=C2/C(=O)Nc3ccc(Br)cc23)cc(Br)c1O
• Target: ATTECs,Autophagy,ATG
• Solubility: DMSO:120 mg/mL (291.94 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.73 mM)

Bioactivity

• In Vitro:
  LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes, reduced mHTT levels in an allele-selective manner, and rescued disease-relevant phenotypes in cells and in vivo in fly and mouse models of Huntington's disease.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ATTECs, Autophagy, Autophagosome-tethering compounds, inhibit, mHTT-LC3 Linker Compound, Inhibitor, LC3 mHTT IN AN1, LC3mHTTINAN1, LC-3-mHTT-IN-AN1, LC3-mHTT-IN-AN1

Compound Identifiers

PubChem CID

1759437