LC3-mHTT-IN-AN1

SKU: orb1220248

Description

LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 486443-73-6
• MW: 411.04
• Purity: >98% (HPLC)
• Formula: C??H?Br?NO?
• SMILES: BrC1=CC=C(C/2=C1)NC(C2=C/C3=CC(Br)=C(C(O)=C3)O)=O
• Target: Autophagy
• Solubility: DMSO : 125 mg/mL (304.11 mM; Need ultrasonic)\n\nH2O : < 0.1 mg/mL (insoluble)

Bioactivity

• In Vitro:
  LC3-mHTT-IN-AN1 (10, 50, 100, and 300 nM) reduces the levels of mHTT in an allele-selective manner in cultured HD mouse neurons.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Autophagy