L-Tyrosine

SKU: orb1310559

Description

L-Tyrosine (L-p-Tyrosine) is the naturally occurring, levorotatory isomer of this aromatic amino acid, which is synthesized in vivo from L-phenylalanine. It serves as a crucial precursor in the biosynthesis of catecholamines, thyroid hormones, and melanin, making it valuable for neuroscience, endocrinology, and cell signaling research in both in vitro and in vivo models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 60-18-4
• MW: 181.19
• Purity: 99.82%
• Formula: C₉H₁₁NO₃
• SMILES: C([C@@H](C(O)=O)N)C1=CC=C(O)C=C1
• Target: Endogenous Metabolite,Amino Acids and Derivatives
• Solubility: DMSO:Insoluble;0.1 M HCl:10 mg/mL (55.19 mM);H2O:Insoluble

Bioactivity

• In Vivo:
  Acute administration of L-tyrosine inhibits malate dehydrogenase and complex II, II–III and IV of the mitochondrial respiratory chain activity in the posterior cortex and liver of rats. The succinate dehydrogenase enzyme and complex I activity are inhibited in the posterior cortex and increased in the striatum.
• In Vitro:
  L-tyrosine in vitro inhibits citrate synthase activity in the posterior cortex. Succinate dehydrogenase activity is increased in the posterior cortex, hippocampus, striatum and liver. Complex I activity is inhibited in the hippocampus, complex II activity is also inhibited in the hippocampus and in the posterior cortex and liver, complex II–III activity is not altered by L-tyrosine and complex IV activity decreased in the posterior cortex.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tyrosine, P-Tyrosine, EndogenousMetabolite, Endogenous Metabolite, LTyrosine, L-Tyrosine, L-p-Tyrosine, L Tyrosine, Amino Acids and Derivatives, AminoAcidsandDerivatives, (S)-Tyrosine

Compound Identifiers

PubChem CID

6057