L-Tryptophan

SKU: orb1224121

Description

An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.

Key Properties

• CAS Number: 73-22-3
• MW: 204.23
• Purity: >98% (HPLC)
• Formula: C₁₁H₁₂N₂O₂
• SMILES: O=C(O)C(N)CC1=CNC2=C1C=CC=C2
• Target: Amino Acids and Derivatives
• Solubility: soluble in Water

Bioactivity

• In Vivo:
  Animal model: Five-week-old C57BL/6 mice. Dosage: 10, 50 kg/mg. Administration: Intraperitoneally; daily; for consecutive three weeks. Result: The concentration of 50 mg/kg/day induced a significant increase in the number of SSEA-4 positive cells. Increased the mRNA levels of Nanog and Oct-4 and the colony-forming ability of mBMSCs with 50 mg/kg/day.
• In Vitro:
  Cell Viability Assay Cell line: pTr2 cell. Concentration: 500, 1000 μM. Incubation time: 48 h. Result: 500 and 1000 μM groups had decreased cell viability by 7% and 22%, respectively, at 48 h posttreatment. Cell Cycle Analysis Cell line: pTr2 cell. Concentration: 500, 1000 μM. Incubation time: 48 h. Result: The percentage of pTr2 cells in the G1 phase increased from 65.70% (control) to 71.37% (500 mM) and 73.86% (1000 mM). Cell Migration Assay Cell line: hBMSCs. Concentration: 10 μM. Incubation time: For three weeks. Result: Exhibited a higher ability for migration than the control group. RT-PCR Cell line: hBMSCs. Concentration: 10 μM. Incubation time: For three weeks. Result: Decreased mRNA levels of adipogenic markers PPARγ and LPL.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tryptophan | NSC 13119 | NSC-13119 | NSC13119 | Ardeytropin | L-Tryptophane

Quick Database Links

Gene Symbol

Amino Acids and Derivatives