Kinetin

SKU: orb1224800

Description

Kinetin is a type of cytokinin, a class of plant hormone that promotes cell division.(In Vitro):Kinetin (N6-furfuryladenine) shows to have a direct effect on superoxide dismutase activity in plants; prevent oxidation of unsaturated acids in plant membranes; slow down development and aging in insects, by reducing their fecundity and increasing the specific activity of catalase; and delay the onset of many age-related characteristics that appear in normal human skin fibroblasts undergoing aging in vitro. Kinetin (70-150 μM) markedly suppressed hydroxyl radical formation by about 41% and 76%, respectively.The plant cytokinin kinetin dramatically increases exon 20 inclusion in RNA isolated from cultured familial dysautonomia (FD) cells.(In Vivo):Kinetin (N6-furfuryladenine) (2-6 mg/kg; injection into the tail vein) effectively prevents ADP-induced acute pulmonary thrombosis in mice.Subjects received 23.5 mg/kg/d for 28 d. An increase in WT IKBKAP mRNA expression in leukocytes was noted after 8 d in six of eight individuals; after 28 d, the mean increase compared with baseline was significant.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 525-79-1
• MW: 215.21
• Purity: >98% (HPLC)
• Formula: C₁₀H₉N₅O
• SMILES: 9H-Purin-6-amine, N-(2-furanylmethyl)-
• Target: Others
• Solubility: DMSO: 8 mg/mL warmed (37.17 mM)

Bioactivity

• In Vivo:
  Kinetin (N6-furfuryladenine) (2-6 mg/kg; injection into the tail vein) effectively prevents ADP-induced acute pulmonary thrombosis in mice. Subjects received 23.5 mg/kg/d for 28 d. An increase in WT IKBKAP mRNA expression in leukocytes was noted after 8 d in six of eight individuals; after 28 d, the mean increase compared with baseline was significant. Animal model: ADP-induced acute pulmonary thrombosis 20-24 g mice (ICR strain). Dosage: 2, 4, 6 mg/kg. Administration: Injection into the tail vein. Result: Reduced mortality to 70%, 40% and 35% at 2, 4, and 6 mg/kg, respectively.
• In Vitro:
  Kinetin (N6-furfuryladenine) shows to have a direct effect on superoxide dismutase activity in plants; prevent oxidation of unsaturated acids in plant membranes; slow down development and aging in insects, by reducing their fecundity and increasing the specific activity of catalase; and delay the onset of many age-related characteristics that appear in normal human skin fibroblasts undergoing aging in vitro. Kinetin (70-150 μM) markedly suppressed hydroxyl radical formation by about 41% and 76%, respectively. The plant cytokinin kinetin dramatically increases exon 20 inclusion in RNA isolated from cultured familial dysautonomia (FD) cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

N6-furfuryladenine | NSC 23119

Quick Database Links

Gene Symbol

Others